| ncRNA name | CCN1 siRNA |
| ncRNA Category | siRNA |
| Disease name | retinopathy of prematurity (ROP) |
| Species | Mus musculus |
| Tissues/Cell_line | corneas |
| Methods | siRNA injection, ADPase staining, immunohistochemistry, Western blot, qRT-PCR |
| Expression pattern | associated |
| Functional description | Intravitreal injection of CCN1 siRNA significantly reduced PI3K/Akt-VEGF pathway expression of the OIR mouse model (all P<0.05). CCN1 siRNA significantly enhanced the avascular area and avascular diameter of OIR model (P<0.05). CCN1 siRNA decreased the levels of IL-1β, IL-6, and TNF-α significantly compared to the OIR group (P<0.05). |
| PubMed ID | 25995618 |
| Year | 2015 |
| Title | The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt-VEGF signaling pathway. |
| Drug-related ncRNA | NO |
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